Updated: 2012-12-30 23:36:40
Dear friends,
I have a problem since one weaks the instrument sarts rebooting can say restrts during programed samole running. if some one have any experience help me .
Updated: 2012-12-28 22:00:00
J Mol Microbiol Biotechnol 2012;22:361–372 (DOI:10.1159/000343921) (Source: Journal of Molecular Microbiology and Biotechnology)
Updated: 2012-12-28 06:16:11
ConclusionsOur results indicate that the FilmArray® Biothreat Panel is a sensitive and selective assay for detecting the genetic signatures of Ba, Ft and Yp.© 2012 No claim to US Government works (Source: Journal of Applied Microbiology)
Updated: 2012-12-28 06:15:57
ConclusionsThe proposed PCR‐based assay may be used for diagnosing and monitoring maize Curvularia leaf spot.
Significance and Impact of the StudyThe semi‐nested PCR assay may provide researchers and laboratory technologists a tool to rapidly detect C. lunata, which causes maize Curvularia leaf spot, compared with histological examination.© 2012 The Authors Letters in Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Letters in Applied Microbiology)
Updated: 2012-12-28 06:15:32
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology FEMS Microbiology Letters Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues Virtual Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL Society Information News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES FEMS Most Cited Articles FEMS Most Read Articles Virtual Issue :
Updated: 2012-12-28 04:00:00
. . : Warning The NCBI web site requires JavaScript to function . more . NCBI Skip to main content Skip to navigation Resources All Resources Chemicals Bioassays BioSystems PubChem BioAssay PubChem Compound PubChem Structure Search PubChem Substance All Chemicals Bioassays Resources . DNA RNA BLAST Basic Local Alignment Search Tool BLAST Stand-alone E-Utilities GenBank GenBank : BankIt GenBank : Sequin GenBank : tbl2asn Genome Workbench Influenza Virus Nucleotide Database PopSet Primer-BLAST ProSplign Reference Sequence RefSeq RefSeqGene Sequence Read Archive SRA Splign Trace Archive UniGene UniSTS All DNA RNA Resources . Data Software BLAST Basic Local Alignment Search Tool BLAST Stand-alone Cn3D Conserved Domain Search Service CD Search E-Utilities GenBank : BankIt GenBank : Sequin
Updated: 2012-12-28 04:00:00
This article aims to review the strategies by which microorganisms thrive in extreme radiation environments and discuss their potential uses in biotechnology and the therapeutic industry. The major challenges that lie ahead are also discussed.
PMID: 23271672 [PubMed - as supplied by publisher] (Source: Applied Microbiology and Biotechnology)MedWorm Sponsor Message: Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
Updated: 2012-12-28 04:00:00
Abstract
Carbapenems resistance among multidrug resistant (CR‐MDR) P. aeruginosa were isolated from tertiary hospitals in Thailand. Decreased expression of oprD mRNA (93.65%) was predominant followed by increased expression of mexAB‐oprM mRNA (92.06%) and mexXY mRNA (63.49%). Interestingly, there were 23 out of 126 (18.25%) isolates which were susceptible to imipenem with down‐regulated oprD expression and non‐up‐regulated mexCD‐oprJ mRNA expression. Metallo‐β‐lactamases production was clearly positive in 24 isolates (18.46%) and weakly positive in 12 isolates (9.23%). Among both of them, imp‐1, imp‐14, and vim‐2 were identified. Hyperproduction of AmpC β‐lactamase was the lowest prevalence rate (3.97%). It could be concluded that CR‐MDR P. aeruginosa clinical i...
Updated: 2012-12-28 04:00:00
In this study, we examined the role of activation of signal transducer and activator of transcription (Stat) 1 phosphorylation with A. phagocytophilum infection, and found it to be markedly increased at day 7 post infection compared to mock‐infected controls. This increase in phosphorylated Stat1 (pStat1) was significantly correlated with IFN‐γ production and inflammatory tissue injury. Since pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN‐γ‐mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention of disease. (Source: Microbiology and Immunology)
Updated: 2012-12-28 04:00:00
This study revealed a novel interaction between MHC II+CD11c− non‐lymphoid cells and lymphoid cells in the accumulation of these non‐lymphoid cells in the spleen during infection with P. yoelii. (Source: Microbiology and Immunology)MedWorm Sponsor Message: Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
Updated: 2012-12-28 04:00:00
Abstract
We recently reported that 3β‐hydroxysterol Δ24‐reductase (DHCR24) is induced by hepatitis C virus (HCV) infection. In addition, upregulation of DHCR24 impaired p53 activity. In human hepatoma HuH‐7 cells, level of DHCR24 expression was higher than normal hepatic cell lines (WRL68) at transcriptional level. The genomic promoter sequence of DHCR24 was characterized and nucleotide substitution were observed in HuH‐7 cells at nucleotide number –1453; G to A, –1420, G to T, –488, A to C, and –200 G to C. The mutations of these sequences from HuH‐7 cell types to WRL68 cell types suppressed DHCR24 gene promoter activity. We further characterized the sequences in hepatocytes from patient tissues. Four HCV positive patient tissues with cirrhosis or HCC (#1, 2, 3, 5) pos...
Updated: 2012-12-28 04:00:00
Abstract
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease that affects patients with cystic fibrosis (CF) and asthmatic patients. Indeed, HLA‐DRB1 alleles have previously been associated with ABPA‐CF susceptibility although HLA‐DQB1 allele associations were not clearly established. Our aim was to study HLA class II associations in our ABPA‐CF patients and determine their role in susceptibility or protection. Patients with ABPA‐CF, CF patients without ABPA, asthmatic patients without ABPA (AST) and healthy controls were included in this study. DNA was extracted by automatic extractor. HLA‐DRB1 and ‐DQB1 genotyping was performed by luminex PCR‐SSO method (OneLambda, CA). Allele specific PCR‐SSP was also performed by high resolution analysis ...
Updated: 2012-12-28 04:00:00
Abstract
Oral keratinocytes and fibroblasts may be the first line of host defense against oral microorganisms. Here, we tested the hypothesis that oral keratinocytes and fibroblasts recognize microbial components via Toll‐like receptors (TLRs) and participate in development of oral inflammation. Our results showed that immortalized oral keratinocytes (RT7), fibroblasts (GT1) and primary cells expressed mRNA of TLRs 1‐10. Interleukin‐8 (IL‐8) production from RT7 cells was induced by treatment with TLR1‐9 except for TLR7 agonist, while, GT1 cells were induced to produce IL‐8 by all TLR agonists tested except for TLR7 and TLR9. GT1 cells showed increased CXCL10 production following treatment with agonists for TLR1/2, TLR3, TLR4 and TLR5, while only those for only TLR3 and TLR5 inc...
Updated: 2012-12-28 04:00:00
An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation. (Source: Microbial Cell Factories)
Updated: 2012-12-28 04:00:00
Conclusions:
We present the HBV deletion distribution patterns and preS deletion substructures in viral genomes that are prevalent in northern China. The accumulation of preS deletion mutants during nucleos(t)ide analog therapy may be due to viral escape from host immuno-surveillance. (Source: BMC Microbiology - Latest articles)
Updated: 2012-12-28 04:00:00
Summary
Egress of Plasmodium falciparum merozoites from host erythrocytes is a critical step in multiplication of blood‐stage parasites. A cascade of proteolytic events plays a major role in degradation of membranes leading to egress of merozoites. However, the signals that regulate the temporal activation and/or secretion of proteases upon maturation of merozoites in intra‐erythrocytic schizonts remain unclear. Here, we have tested the role of intracellular Ca2+ in regulation of egress of P. falciparum merozoites from schizonts. A sharp rise in intracellular Ca2+ just before egress, observed by time‐lapse video microscopy, suggested a role for intracellular Ca2+ in this process. Chelation of intracellular Ca2+ with chelators such as BAPTA‐AM or inhibition of Ca2+ release from in...
Updated: 2012-12-28 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Molecular Microbiology Molecular Microbiology Early View Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES 3D Interactive Images Faculty of 1000 Prizes Awarded by Molecular Microbiology Virtual Special Issues Wiley Job
Updated: 2012-12-28 04:00:00
Skip to main page content Home Current issue Archive Papers in Press Minireviews Reports Classics Reflections Papers of the Week QUICK SEARCH : Author : Keyword : Year : Vol : Page GO Advanced Search Browse the Archive Advertisement Advertisement Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-mannose Jakob Engel 1 Philipp S . Schmalhorst 1 2 and Françoise H . Routier 3 From the Department of Cellular Chemistry , OE 4330, Hannover Medical School , Carl-Neuberg-Strasse 1, 30625 Hannover , Germany 3 To whom correspondence should be addressed . Tel . 49-511-5329807 Fax : 49-511-5328801 E-mail : Routier.Francoise{at mh-hannover.de 1 Both authors contributed equally to this work . : Background Understanding the mechanisms of cell wall biogenesis is
Updated: 2012-12-28 04:00:00
In conclusion, we have demonstrated that MtbESAT-6 possesses a unique membrane-interacting activity that is not found in MsESAT-6 and established the utility of rigorous biochemical approaches in dissecting the virulence of M. tuberculosis. (Source: Journal of Biological Chemistry)
Updated: 2012-12-27 04:00:00
Conclusions:
The A. niger McoA, McoB, and McoG enzymes showed clearly different catalytic properties. Yellow McoB showed broad substrate specificity, catalyzing the oxidation of several phenolic compounds commonly present in different industrial effluents. It also harbored high decolorization and detoxification activity with the synthetic dye malachite green, showing to have an interesting potential as a new industrial biocatalyst. (Source: Microbial Cell Factories)
Updated: 2012-12-27 04:00:00
Conclusions:
The VIDISCR method was able to identify known virus isolates and a novel isolate of Getah virus from infected mice. Phylogenetic analysis indicated that the YN08 isolate was more closely related to the Hebei HB0234 strain than the YN0540 strain, and more genetically distinct from the MM2021 Malaysia primitive strain. (Source: BMC Microbiology - Latest articles)
Updated: 2012-12-27 04:00:00
: Log on BioMed Central Journals Gateways 3.04 Search BMC Microbiology BioMed Central for Go Advanced search Home Articles Authors Reviewers About this journal My BMC Microbiology BMC Microbiology Volume 12 Viewing options Abstract Provisional PDF 317KB Associated material PubMed record About this article Readers' comments Related literature Cited by on Google blog search Other articles by authors on Google Scholar Weissbrodt DG Shani N Sinclair L Lefebvre G Rossi P Maillard J Rougemont J Holliger C on PubMed Weissbrodt DG Shani N Sinclair L Lefebvre G Rossi P Maillard J Rougemont J Holliger C Related articles pages on Google on Google Scholar on PubMed Tools Download references Email to a friend Order reprints Post a comment Share this article Tweet More options . Citeulike Connotea
Updated: 2012-12-27 04:00:00
ConclusionsA new thermolabile subtilisin‐like protease has been successfully cloned and analysed, and an important hot spot in the evolution of the cold adaptation and substrate specificity of this enzyme was identified and tested.
Significance and Impact of the StudyThis work reports a new cold‐adapted protease with a vast representation amongst Antarctic genus, suggesting therefore its evolutionary success in this cold environment. Likewise, important sites for genetic potentiation have been identified, which are extrapolated to other enzymes of the same kind. (Source: Journal of Applied Microbiology)
Updated: 2012-12-27 04:00:00
ConclusionsThe specific FA in circulation water seems to be the important factor, which relates to the AOB and AEA community shifts in the biofilter besides ammonium and pH.
Significance and Impact of the StudyOne of the key factors for regulating AEA and AOB communities was proposed that is useful for optimizing biofiltration technology. (Source: Journal of Applied Microbiology)
Updated: 2012-12-27 04:00:00
ConclusionsThe approach used in this study pointed out the need for a closer analysis of the complex interaction between spores and wipe material because a substantial percentage of spores were lost to the wipe.
Significance and Impact of the StudyThe recovery balance, in association with independent controls, provides an account for error contribution and potential variability on each step of the sampling protocol. The approach is not meant to be a replacement for field or laboratory validation of wipe recoveries but promote the development of new collection methodologies and support protocol optimization in laboratory settings. (Source: Journal of Applied Microbiology)
Updated: 2012-12-27 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Applied Microbiology Journal of Applied Microbiology Early View Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues Virtual Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL Society Information News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Virtual Issue on Biodefence Virtual Issue on Campylobacter Virtual
Updated: 2012-12-27 04:00:00
, Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology FEMS Microbiology Letters Early View Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues Virtual Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL Society Information News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES FEMS Most Cited Articles FEMS Most Read Articles Virtual Issue :
Updated: 2012-12-26 04:00:00
ConclusionMannanoligossacharides and threonine act synergistically, resulting in improved intestinal environment and recovery after Salmonella inoculation.
Significance and impact of studyNutritional approaches may be useful to prevent Salmonella infection in the first week and putative carcass contamination at slaughter. This is the first report on the possible synergistic effect of mannanoligosaccharides and threonine, and further studies should be performed including performance, microbiota evaluation, composition of intestinal mucins and immune assessment.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsWe conclude that ETEC is continuously present in water and biofilms in household water reservoirs in Dhaka which has a high prevalence of ETEC diarrhea. The frequency of biofilms with ETEC was significantly associated (p < 0.008) to seasonal epidemic peaks of ETEC diarrhea.
Significance and impact of the studyWe show for the first time that enterotoxigenic Escherichia coli (ETEC), the causative agent of acute watery diarrhea and travelers’ diarrhea is present in biofilms in household water tanks in Dhaka, Bangladesh.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsP. resticulosum demonstrated microbial pH‐stable‐pigment production potential using a xylose or CMC‐, and N‐source, supplemented waste stream cellulose culture medium.
Significance and Impact of StudyCorn derived, waste stream cellulose can be used as a culture medium for fungal pigment production. Such application provides a process for agricultural waste stream resource reuse for production of compounds in increasing demand.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsBesides chitosan's molecular weight and bacterial genus/species, the antimicrobial activity of chitosan was also influenced largely by the susceptibility testing method used.
Significance and Impact of StudyThis is the first study that comparatively evaluated these diffusion and dilution methods, particularly two quantitative methods (agar dilution and broth microdilution), to assess the antimicrobial activity of two water‐soluble chitosans against a large number of foodborne pathogens. The study highlights the need for standardized methods to be used in evaluating chitosan's antimicrobial properties in future studies.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsCS7 and CS8 are two new highly cellulolytic and ethanologenic C. thermocellum strains.
Significance and Impact of the StudyFirst report of applying the cloning‐RFLP‐sequencing approach for purity confirmation of the isolates beside conventional methods. Strains CS7 and CS8 might be of potential application in research and development of cellulosic bioconversion.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)<bMedWorm Sponsor Message: Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
Updated: 2012-12-26 04:00:00
ConclusionDrinking water, especially from untreated water supplies, can be source of STEC strains potentially pathogenic for humans.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsResults suggest that the bactericidal activity of phlorotannins is a function of the level of polymerisation of the compounds. By monitoring intermediary compounds during the anaerobic digestion of phlorotannins, it was also found that higher energy consumption is required by microorganisms for survival under stress induced by phlorotannins.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsT. elegans represents a promising fungus for the successful valorization of sugar‐based lignocellulosic residues into microbial lipids of high nutritional and pharmaceutical interest.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionFCM coupled with the BaclightTM kit makes it possible to count O. oeni cells during MLF with a perfect correlation with the plate count method.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)MedWorm Sponsor Message: Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
Updated: 2012-12-26 04:00:00
ConclusionsSporulation in complex conditions such as biofilms and surface swarming colonies increases heat resistance and dormancy of spores.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
ConclusionsThe IS6110‐TaqMan was rapid, sensitive and specific for the diagnosis of pulmonary TB.© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology (Source: Journal of Applied Microbiology)
Updated: 2012-12-26 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Applied Microbiology Letters in Applied Microbiology Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues Virtual Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL Society Information News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Antimicrobials Virtual Issue Wiley Job Network Wine
Updated: 2012-12-26 04:00:00
Summary
We have previously shown that benzamidine‐type compounds can inhibit the activity of arginine‐specific cysteine proteinases (gingipains HRgpA and RgpB); well‐known virulence factors of Porphyromonas gingivalis. They also hinder in vitro growth of this important periodontopathogenic bacterium. Apparently growth arrest is not associated with their ability to inhibit these proteases, because pentamidine, which is a 20‐fold less efficient inhibitor of gingipain than 2,6‐bis‐(4‐amidinobenzyl)‐cyclohexanone (ACH), blocked P. gingivalis growth far more effectively. To identify targets for benzamidine‐derived compounds other than Arg‐gingipains, and to explain their bacteriostatic effects, P. gingivalis ATCC 33277 and P. gingivalis M5‐1‐2 (clinical isolate) cell ...
Updated: 2012-12-26 04:00:00
Conclusions: Among immunocompetent patients with pulmonary M. xenopi isolation, cavitation and large nodules predict fulfilling microbiological disease criteria, while bronchiectasis and small nodules predict symptoms. (Source: Respirology)
Updated: 2012-12-26 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Food Science Technology General Introductory Food Science Technology International Journal of Dairy Technology Early View Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL Society Information News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Extended Shelf Life Milk Job Vacancies Wiley Job Network Original
Updated: 2012-12-26 04:00:00
This study examines the interaction of gonococci (GC) with polarized epithelial cells. We show that viable GC preferentially localize at the apical side of the cell‐cell junction in polarized endometrial and colonic epithelial cells, HEC‐1‐B and T84. In GC infected cells, continuous apical junctional complexes are disrupted, and the junction‐associated protein β‐catenin is redistributed from the apical junction to the cytoplasm and to GC adherent sites, however overall cellular levels remain unchanged. This redistribution of junctional proteins is associated with a decrease in the ‘fence’ function of the apical junction but not its ‘gate’ function. Disruption of the apical junction by removing calcium increases GC transmigration across the epithelial monolayer. GC inocul...
Updated: 2012-12-26 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology Cellular Microbiology Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Faculty of 1000 Parasitology Virtual Special Issue Posters Virology Virtual Special Issue Wiley Job Network
Updated: 2012-12-26 04:00:00
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology Cellular Microbiology Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Faculty of 1000 Parasitology Virtual Special Issue Posters Virology Virtual Special Issue Wiley Job Network
Updated: 2012-12-26 04:00:00
Summary
Wounds are known to serve as portals of entry for group A Streptococcus (GAS). Subsequent tissue colonization is mediated by interactions between GAS surface proteins and host extracellular matrix components. We recently reported that the streptococcal collagen‐like protein‐1, Scl1, selectively binds the cellular form of fibronectin (cFn) and also contributes to GAS biofilm formation on abiotic surfaces. One structural feature of cFn, which is predominantly expressed in response to tissue injury, is the presence of a spliced variant containing extra domain A (EDA/EIIIA). We now report that GAS biofilm formation is mediated by the Scl1 interaction with EDA‐containing cFn. Recombinant Scl1 proteins that bound cFn also bound recombinant EDA within the C‐C’ loop region recogn...
Updated: 2012-12-26 04:00:00
Early secretory and endoplasmic reticulum (ER)-localized proteins that are terminally misfolded or misassembled are degraded by a ubiquitin- and proteasome-mediated process known as ER-associated degradation (ERAD). Protozoan pathogens, including the causative agents of malaria, toxoplasmosis, trypanosomiasis, and leishmaniasis, contain a minimal ERAD network relative to higher eukaryotic cells, and, because... (Source: Proceedings of the National Academy of Sciences)
Updated: 2012-12-26 04:00:00
We present crystal structures of CDI toxin/immunity complexes from Escherichia coli EC869 and Burkholderia pseudomallei 1026b. Despite sharing little sequence identity, the toxin domains are structurally similar and have homology to endonucleases. The EC869... (Source: Proceedings of the National Academy of Sciences)MedWorm Sponsor Message: Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
Updated: 2012-12-26 04:00:00
Plasmodium falciparum causes the deadliest form of human malaria. Its virulence is attributed to its ability to modify the infected RBC and to evade human immune attack through antigenic variation. Antigenic variation is achieved through tight regulation of antigenic switches between variable surface antigens named “P. falciparum erythrocyte membrane protein-1”... (Source: Proceedings of the National Academy of Sciences)
Updated: 2012-12-26 00:16:37
Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology Cellular Microbiology Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Faculty of 1000 Parasitology Virtual Special Issue Posters Virology Virtual Special Issue Wiley Job Network
Updated: 2012-12-26 00:15:39
Summary
Toxoplasma gondii belongs to the coccidian‐subgroup of the Apicomplexa phylum. The Coccidia are obligate intracellular pathogens that establish infection in their mammalian host via the enteric route. These parasites lack a mitochondrial pyruvate dehydrogenase complex but have preserved the degradation of branched‐chain amino acids (BCAA) as a possible pathway to generate acetyl‐CoA. Importantly, degradation of leucine, isoleucine and valine could lead to concomitant accumulation of propionyl‐CoA, a toxic metabolite that inhibits cell growth. Like fungi and bacteria, the Coccidia possess the complete set of enzymes necessary to metabolize and detoxify propionate by oxidation to pyruvate via the 2‐methylcitrate cycle (2‐MCC). Phylogenetic analysis provides evidence that ...
Updated: 2012-12-24 05:40:45
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Updated: 2012-12-24 04:00:00
. Skip to Main Content Home Help PUBLICATIONS BROWSE BY SUBJECT RESOURCES ABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED FORGOTTEN PASSWORD INSTITUTIONAL LOGIN Home Microbiology Virology Microbiology Virology Cellular Microbiology Accepted Articles Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENU Journal Home FIND ISSUES Current Issue All Issues FIND ARTICLES Early View Accepted Articles GET ACCESS Subscribe Renew FOR CONTRIBUTORS OnlineOpen Author Guidelines Submit an Article ABOUT THIS JOURNAL News Overview Editorial Board Permissions Advertise Contact SPECIAL FEATURES Faculty of 1000 Parasitology Virtual Special Issue Posters Virology Virtual Special Issue Wiley Job
Updated: 2012-12-24 04:00:00
Summary
The small matrix protein Z of arenaviruses has been identified as the main driving force to promote viral particle production at the plasma membrane. Although multiple functions of Z in the arenaviral life cycle have been uncovered, the mechanism of intracellular transport of Z to the site of virus budding is poorly understood and cellular motor proteins that mediate Z trafficking remain to be identified. In the present study, we report that the Z protein of the Old World arenavirus Lassa virus (LASV) interacts with the kinesin family member 13A (KIF13A), a plus end‐directed microtubule‐dependent motor protein. Plasmid‐driven overexpression of KIF13A results in relocalization of Z to the cell periphery, while functional blockage of endogenous KIF13A by overexpression of a dom...
Updated: 2012-12-24 04:00:00
Abstract
A wide range of biopeptides potentially able to lower blood pressure through inhibition of the Angiotensin‐I Converting Enzyme are produced in fermented foods by proteolytic starter cultures. This work applies a procedure based on recombinant DNA technologies for the synthesis and expression of three ACE‐inhibitory peptides using a probiotic cell factory. ACE‐inhibitory genes and their pro‐active precursors were designed, synthesized by PCR, and cloned in Escherichia coli; after which, they were cloned into the pAM1 E. coli‐bifidobacteria shuttle vector. After E. coli transformation, constructs carrying the six recombinant clones were electrotransferred into the Bifidobacterium pseudocatenulatum M115 probiotic strain. Interestingly, five out of the six constructs proved ...
Updated: 2012-12-24 04:00:00
Abstract
The dasD gene is located just downstream of the dasABC gene cluster, encoding components of an ABC transporter for uptake of a chitin‐degradation product N,N’‐diacetylchitobiose [(GlcNAc)2] in Streptomyces coelicolor A3(2). To clarify the roles of the DasD protein in the degradation and assimilation of chitin, we obtained and characterized a recombinant DasD protein and a dasD‐null mutant of S. coelicolor A3(2). The recombinant DasD protein produced in Escherichia coli showed N‐acetyl‐β‐D‐glucosaminidase (GlcNAcase) activity and its optimum temperature and pH were 40°C and 7, respectively. dasD transcription was strongly induced in the presence of chitin, weakly by chitosan, but not by cellulose or xylan in S. coelicolor A3(2). Immuno‐blot analysis demonstrated...
Updated: 2012-12-24 04:00:00
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