• Reprogramming Cancer Cells into Normal Somatic Cells

    Updated: 2021-03-26 19:54:36
    Cell reprogramming involves changing the expression of top-level regulatory genes, picking targets that will radically change cell form and function. Given a suitable recipe, many of which have been established, forms of cell reprogramming can be used to change somatic cells into stem cells, or change somatic cells of one type into somatic cells of another type. In the other direction, numerous approaches can be used to guide stem cells into differentiating into varieties of somatic cell. A cancerous cell adopts some of the characteristics of a stem cell, primarily the unrestricted replication that is the hallmark of cancer, and sometimes some of the characteristics of other somatic cell types. Cancer stem cells are thought to exist for many forms of cancer, a class of […]

  • The Tripartite Phenotype of Aging

    Updated: 2021-03-26 10:22:25
    Here, researchers advocate for a greater consideration of the role of random chance at the cellular level in the variations in life span exhibited by individuals of any given species. Why do people age at different rates and why does human life span exhibit a wide range? Exploration of human genetic data increasingly suggests that very little of this variation between individuals is due to our genes. That in turn might suggest that stochastic processes of damage and dysfunction are of greater importance to variations in aging than was previously thought to be the case by the research community. Researchers introduced the "Tripartite Phenotype of Aging" as a new conceptual model that addresses why lifespan varies so much, even among human identical twins who share […]

  • Considering Rate-Limiting Processes in the Progression of Aging

    Updated: 2021-03-26 10:11:22
    In this paper, the author argues for greater emphasis to be placed on identifying rate-limiting processes in aging, here termed "flux-controlling" processes. One can tinker with various aspects of cellular metabolism connected to any one given molecule or class of molecules, and do so in many different ways, but any given approach may or may not interact with a rate-limiting step. If it doesn't, then the outcome will not tell us all that much about whether or not this molecule, this process, is important in aging. Let us imagine that Gustav Embden (1874-1933), one of the ingenious discoverers of glycolysis, would have had modern transgenic techniques at hand and intended to use them to investigate the role of phosphoglycerate kinase (PGK) in the biochemical degradation […]

  • Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice

    Updated: 2021-03-25 19:50:06
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 25th , 2021 Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice Permalink No Comments Yet Add a Comment Posted by Reason D-galactose is often used by researchers in order to induce aging-like symptoms in mice . It is a damaging compound , provoking oxidative stress inflammation and cellular

  • Evidence for Head Injuries to Accelerate Cognitive Decline in Following Decades

    Updated: 2021-03-25 10:22:54
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 25th , 2021 Evidence for Head Injuries to Accelerate Cognitive Decline in Following Decades Permalink Read 1 Comment Add a Comment Posted by Reason Researchers here present epidemiological evidence for head injuries to leave permanent consequences that accelerate later cognitive decline .

  • Mitochondrial DNA Heteroplasmy in the Aging Heart

    Updated: 2021-03-25 10:11:35
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 25th , 2021 Mitochondrial DNA Heteroplasmy in the Aging Heart Permalink No Comments Yet Add a Comment Posted by Reason Every cell contains hundreds of mitochondria bacteria-like structures that carry their own small genome the mitochondrial DNA Mitochondria replicate like bacteria to maintain their

  • A Discussion of Systemic Inflammation and its Contribution to Dementia

    Updated: 2021-03-24 19:17:24
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 24th , 2021 A Discussion of Systemic Inflammation and its Contribution to Dementia Permalink No Comments Yet Add a Comment Posted by Reason A growing faction within the research community has come to view chronic inflammation as one of the most important mechanisms that contribute to degenerative

  • Calorie Restriction Slows Aging of the Gut Microbiome in Mice

    Updated: 2021-03-24 10:20:12
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 24th , 2021 Calorie Restriction Slows Aging of the Gut Microbiome in Mice Permalink No Comments Yet Add a Comment Posted by Reason The gut microbiome is known to change in harmful ways with advancing age . In old people there are too many inflammatory microbes , versus too few microbes generating

  • Insight into the Dysregulation of Myelin Maintenance in the Aging Brain

    Updated: 2021-03-23 20:11:31
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 23rd , 2021 Insight into the Dysregulation of Myelin Maintenance in the Aging Brain Permalink No Comments Yet Add a Comment Posted by Reason Today's research materials report on an investigation of the age-related loss of myelin in the nervous system The insulating sheath that surrounds nerves is

  • anti-aging-gods-way.com aging gods way Resources and Information

    Updated: 2021-03-21 23:13:42
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